Ketamine
What is Ketamine?
Its not just you. Its not just pain that won't go away or depression that won't lift. It is actual physical brain changes that can occur weeks after weeks of depressive and painful stimulations. Depression leads to imbalances of dopamine, norepinephrine and serotonin, all chemicals needed for normal moods and brain function. Chronic stress from pain and depression leads to reductions in neuron connections and actual atrophy of brain structures. That's why some medications and therapies are just not enough. Ketamine reverses these detrimental effects. Positive symptom changes can be seen up to 24 hours after first infusion. A series of 6 infusions produces antidepressant effects that can last weeks, even months. You are not alone, there are options. Get help today.
Ketamine has long been used in anesthetic practices since its introduction in 1962. It was first known as a "dissociative anesthetic" and found useful especially in battlefields and military healthcare for its quick action anesthetic and analgesic properties for painful procedures.
It is a derivative of phencyclidine and mainly acts as an antagonist of the N-methyl-D-asparate (NMDA) receptor, targeting glutamate, which is an excitatory amino acid neurotransmitter.
Recently, studies have shown that the use of ketamine can also be beneficial in the treatment of depression (TRD & MDD), suicidal ideation, pain, CRPS, PTSD, OCD, fibromyalgia, migraines, and many many more debilitating disorders. The NIH has coined it as the "most important breakthrough in antidepressant treatment in decades."
Ketamine effects are thought to be a result of increased neuronal signaling and connectivity, synaptic plasticity and increased growth of dendritic spine synapses along with an increase in brain-derived neurotrophic factor (BDNF); all things that are decreased or lost in depressive disorders.
The mechanism of action for ketamine's effect in chronic pain disorders or CRPS is hypothesized as long-term DEsensitization of the NMDA receptor that has been excessively stimulated through the chronic pain disorder process that lead to neuronal degenerative changes. Ketamine has been shown to reverse this damage.
See below for links to research articles. Follow us on Facebook and Instagram for updates.
https://cen.acs.org/biological-chemistry/biochemistry/Ketamine-helps-neurons-regrow-lost/97/i15